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1

Evolution of strategies to improve preclinical cardiac safety testing

Gintant, Gary, Sager, Philip T., Stockbridge, Norman

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 510 KB

english, 2016

2

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

Gilbert J. Diaz, Katina Daniell, Sandra T. Leitza, Ruth L. Martin, Zhi Su, Jeffrey S. McDermott, Bryan F. Cox, Gary A. Gintant

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2004

Language:

english

File:

PDF, 421 KB

english, 2004

3

ILSI-HESI cardiovascular safety subcommittee initiative: Evaluation of three non-clinical models of QT prolongation

Laurie A. Hanson, Alan S. Bass, Gary Gintant, Scott Mittelstadt, David Rampe, Karluss Thomas

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2006

Language:

english

File:

PDF, 273 KB

english, 2006

4

Assessing concordance of nonclinical and clinical QT data: The ILSI-HESI cardiovascular safety subcommittee initiative re-visited

Matt Skinner, Jean-Pierre Valentin, Gary Gintant, John Koerner, Syril Pettit, Todd Wisialowski

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 73 KB

english, 2012

5

Advances in Cardiac Cellular Electrophysiology: Implications for Automaticity and Therapeutics

Gintant, G A, Cohen, I S

Journal:

Annual Review of Pharmacology

Year:

1988

Language:

english

File:

PDF, 761 KB

english, 1988

6

Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells

Antzelevitch, C., Sicouri, S., Litovsky, S. H., Lukas, A., Krishnan, S. C., Di Diego, J. M., Gintant, G. A., Liu, D. W.

Journal:

Circulation Research

Year:

1991

Language:

english

File:

PDF, 4.77 MB

english, 1991

7

The Evolving Roles of Human iPSC-Derived Cardiomyocytes in Drug Safety and Discovery

Gintant, Gary, Fermini, Bernard, Stockbridge, Norman, Strauss, David

Journal:

Year:

2017

Language:

english

File:

PDF, 694 KB

english, 2017

8

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs

Koshman, Yevgeniya E., Wilsey, Amanda S., Bird, Brandan M., Endemann, Aimee L., Sadilek, Sabine, Treadway, Jessica, Martin, Ruth L., Polakowski, James S., Gintant, Gary A., Mittelstadt, Scott W.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2020

File:

PDF, 900 KB

2020

9

Drug-induced QT prolongation: Concordance of preclinical canine model in relation to clinical outcome

Koshman, Yevgeniya E., Wilsey, Amanda S., Bird, Brandan M., Gintant, Gary A., Polakowski, James S., Mittelstadt, Scott W.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2020

File:

PDF, 1.09 MB

2020

10

Predictive, non-GLP models of secondary pharmacodynamics: putting the best compounds forward

Glenn A Reinhart, Ryan M Fryer, Mark A Osinski, James S Polakowski, Bryan F Cox, Gary A Gintant

Journal:

Current Opinion in Chemical Biology

Year:

2005

Language:

english

File:

PDF, 136 KB

english, 2005

11

Microprocessor controlled trituration device for the dissociation of cardiac and other tissues

N. B. Datyner, G. A. Gintant, I. S. Cohen

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1985

Language:

english

File:

PDF, 362 KB

english, 1985

12

Versatile temperature controlled tissue bath for studies of isolated cells using an inverted microscope

N. B. Datyner, G. A. Gintant, I. S. Cohen

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1985

Language:

english

File:

PDF, 548 KB

english, 1985

13

Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine

Gary A. Gintant, Brian F. Hoffman

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1984

Language:

english

File:

PDF, 1.13 MB

english, 1984

14

Pharmacological characterization of P2X7receptors in rat peritoneal cells

Y.-W. Chen, D. L. Donnelly-Roberts, M. T. Namovic, G. A. Gintant, B. F. Cox, M. F. Jarvis, R. R. Harris

Journal:

Inflammation Research

Year:

2005

Language:

english

File:

PDF, 281 KB

english, 2005

15

ALTERING EXTRACELLULAR POTASSIUM CONCENTRATION DOES NOT MODULATE DRUG BLOCK OF HUMAN ETHER-A-GO-GO-RELATED GENE (hERG) CHANNELS

James T Limberis, Zhi Su, Bryan F Cox, Gary A Gintant, Ruth L Martin

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2006

Language:

english

File:

PDF, 295 KB

english, 2006

16

The ‘overly-sensitive’ heart: sodium channel block and QRS interval prolongation

Gary A Gintant, David J Gallacher, Michael K Pugsley

Journal:

British Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 295 KB

english, 2011

17

ABT-089: Pharmacological Properties of a Neuronal Nicotinic Acetylcholine Receptor Agonist for the Potential Treatment of Cognitive Disorders

Lynne E. Rueter, David J. Anderson, Clark A. Briggs, Diana L. Donnelly-Roberts, Gary A. Gintant, Murali Gopalakrishnan, Nan-Horng Lin, Mark A. Osinski, Glenn A. Reinhart, Michael J. Buckley, Ruth L. M

Journal:

CNS Drug Reviews

Year:

2004

Language:

english

File:

PDF, 150 KB

english, 2004

18

Quinidine-Induced Early Afterdepolarizations and Triggered Activity

CHARLES ANTZELEVITCH, JORGE M. DAVIDENKO, SERGE SICOURI, LAWRENCE COHEN, ARTHUR IODICE, ROBERT GOODROW, GARY A. GINTANT

Journal:

Journal of Cardiovascular Electrophysiology

Year:

1989

Language:

english

File:

PDF, 5.39 MB

english, 1989

19

Block of hERG channel by ziprasidone: Biophysical properties and molecular determinants

Zhi Su, Jun Chen, Ruth L. Martin, Jeffrey S. McDermott, Bryan F. Cox, Murali Gopalakrishnan, Gary A. Gintant

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 473 KB

english, 2006

20

Functional consequences of methionine oxidation of hERG potassium channels

Zhi Su, James Limberis, Ruth L. Martin, Rong Xu, Katrin Kolbe, Stefan H. Heinemann, Toshinori Hoshi, Bryan F. Cox, Gary A. Gintant

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 780 KB

english, 2007

21

Electrophysiologic characterization of a novel hERG channel activator

Zhi Su, James Limberis, Andrew Souers, Philip Kym, Ann Mikhail, Kathryn Houseman, Gilbert Diaz, Xiaoqin Liu, Ruth L. Martin, Bryan F. Cox, Gary A. Gintant

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 345 KB

english, 2009

22

A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current

Zhi Su, Deborah L. Widomski, Xiaoqin Liu, James T. Limberis, Jonathon Green, Gilbert Diaz, Ruth L. Martin, Bryan F. Cox, Gary A. Gintant

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 416 KB

english, 2010

23

Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

Gary A. Gintant

Journal:

Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 648 KB

english, 2008

24

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

Journal:

Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 515 KB

english, 2011

25

The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and d, l-sotalol

James T. Limberis, Jeff S. McDermott, Heinz J. Salmen, Zhi Su, Ann Mikhail, Jonathon R. Green, Bryan F. Cox, Gary A. Gintant, Ruth L. Martin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 634 KB

english, 2007

26

AN IN VITRO EXAMINATION OF DELAYED REPOLARIZATION: HOW PLASMA PROTEIN BINDING INFLUENCES DRUG EFFECTS

James T. Limberis, Jeffrey S. McDermott, Heinz J. Salmen, Zhi Su, Ann Mikhail, Jonathon R. Green, Gary A. Gintant, Ruth L. Martin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 59 KB

english, 2007

27

Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics

Hugo M. Vargas, Alan S. Bass, Alexander Breidenbach, Hal S. Feldman, Gary A. Gintant, Alexander R. Harmer, Bronagh Heath, Peter Hoffmann, Armando Lagrutta, Derek Leishman, Nick McMahon, Scott Mittelst

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2008

Language:

english

File:

PDF, 190 KB

english, 2008

28

Comparison of cardiovascular effects in conscious and pentobarbital anesthetized dogs

James Polakowski, R.M. Fryer, G.A. Gintant, S.W. Mittelstadt, B.F. Cox

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2008

Language:

english

File:

PDF, 54 KB

english, 2008

29

Cardiovascular effects of torcetrapib in conscious and pentobarbital anesthetized dogs

S.W. Mittelstadt, R.A. Nelson, L.C. Preusser, A.J. King, A.J. Kempf-Grote, K.C. Marsh, G.A. Gintant, B.F. Cox, J.S. Polakowski

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2009

Language:

english

File:

PDF, 55 KB

english, 2009

30

Ventricular rate adaptation: A novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds

Jonathon R. Green, Gilbert J. Diaz, James T. Limberis, Kathryn A. Houseman, Zhi Su, Ruth L. Martin, Bryan F. Cox, Stan Kantor, Gary A. Gintant

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 634 KB

english, 2011

31

An improved method of evaluation of drug-evoked changes in gastric emptying in mice

M.A. Osinski, T.R. Seifert, B.F. Cox, G.A. Gintant

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2002

Language:

english

File:

PDF, 145 KB

english, 2002

32

Site of action of local anesthetics on heart fibers

Lawrence H. Frame, Gary A. Gintant, Brian F. Hoffman

Journal:

The American Journal of Cardiology

Year:

1981

Language:

english

File:

PDF, 153 KB

english, 1981

33

The influence of molecular form on the interaction of local anesthetic-type antiarrhythmic agents with canine cardiac sodium channels

G.A. Gintant, B.F. Hoffman, R.E. Naylor

Journal:

The American Journal of Cardiology

Year:

1982

Language:

english

File:

PDF, 143 KB

english, 1982

34

Different local anesthetic characteristics of charged and uncharged forms of lidocaine and other antiarrhythmic drugs in canine cardiac purkinje fibers

Gary A. Gintant, Brian F. Hoffman

Journal:

The American Journal of Cardiology

Year:

1982

Language:

english

File:

PDF, 153 KB

english, 1982

35

A novel Na+-dependent slow current component in canine cardiac Purkinje fibers

Gary A. Gintant

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1989

Language:

english

File:

PDF, 98 KB

english, 1989

36

Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers

Xiaoqin Liu, James T. Limberis, Zhi Su, Kathryn Houseman, Gilbert J. Diaz, Gary A. Gintant, Bryan F. Cox, Ruth L. Martin

Journal:

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

37

Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel

Zhi Su, Ruth Martin, Bryan F. Cox, Gary Gintant

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2004

Language:

english

File:

PDF, 754 KB

english, 2004

38

How do the top 12 pharmaceutical companies operate safety pharmacology?

Lorna Ewart, David J. Gallacher, Gary Gintant, Jean-Michel Guillon, Derek Leishman, Paul Levesque, Nick McMahon, Lou Mylecraine, Martin Sanders, Willi Suter, Rob Wallis, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 238 KB

english, 2012

39

An analysis of safety pharmacology operations across the top 12 pharmaceutical companies

Lorna Ewart, David Gallacher, Gary Gintant, Jean-Michel Guillon, Derek Leishman, Nick McMahon, Paul Levesque, Lou Mylecraine, Willi Suter, Martin Sanders, Rob Wallis, Jean Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 56 KB

english, 2012

40

Integrated and translational nonclinical in vivo cardiovascular risk assessment: Gaps and opportunities

Berridge, Brian R., Hoffmann, Peter, Turk, James R., Sellke, Frank, Gintant, Gary, Hirkaler, Gerald, Dreher, Kevin, Schultze, A. Eric, Walker, Dana, Edmunds, Nick, Halpern, Wendy, Falls, James, Sander

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 198 KB

english, 2013

41

Saturation of the internal sodium site of the sodium pump can distort estimates of potassium affinity

Cohen, I., Falk, R., Gintant, G.

Journal:

Biophysical Journal

Year:

1984

Language:

english

File:

PDF, 694 KB

english, 1984

42

Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers

Gintant, G.A., Datyner, N.B., Cohen, I.S.

Journal:

Biophysical Journal

Year:

1984

Language:

english

File:

PDF, 589 KB

english, 1984

43

Gating of delayed rectification in acutely isolated canine cardiac Purkinje myocytes. Evidence for a single voltage-gated conductance

Gintant, G.A., Datyner, N.B., Cohen, I.S.

Journal:

Biophysical Journal

Year:

1985

Language:

english

File:

PDF, 698 KB

english, 1985

44

Temperature Effects on Pharmacologic Enhancement of L-Type Calcium Current

Su, Zhi, Liu, Xiaoqin, Martin, Ruth L., Cox, Bryan F., Gintant, Gary A.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 79 KB

english, 2012

45

Ions, equations and electrons: the evolving role of computer simulations in cardiac electrophysiology safety evaluations

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 159 KB

english, 2012

46

The evaluation and management of drug effects on cardiac conduction (PR and QRS Intervals) in clinical development

Nada, Adel, Gintant, Gary A., Kleiman, Robert, Gutstein, David E., Gottfridsson, Christer, Michelson, Eric L., Strnadova, Colette, Killeen, Matthew, Geiger, Mary Jane, Fiszman, Mónica L., Koplowitz, L

Journal:

American Heart Journal

Year:

2013

Language:

english

File:

PDF, 358 KB

english, 2013

47

Assessment of drug-induced increases in blood pressure during drug development: Report from the Cardiac Safety Research Consortium

Sager, Philip, Heilbraun, Jeffrey, Turner, J. Rick, Gintant, Gary, Geiger, Mary J., Kowey, Peter R., Mansoor, George A., Mendzelevski, Boaz, Michelson, Eric L., Stockbridge, Norman, Weber, Michael A.,

Journal:

American Heart Journal

Year:

2013

Language:

english

File:

PDF, 282 KB

english, 2013

48

Cannabinoid (CB) Receptors are not Involved in A-955840 Induced Negative Inotropic Effects in Isolated Cardiac Myocytes

Su, Zhi, Diaz, Gilbert, Preusser, Lee, Liu, Xiaoqin, Dart, Michael, Yao, Betty, Meyer, Michael, Limberis, James, Green, Jonathon, Polakowski, James, Martin, Ruth L., Cox, Bryan F., Gintant, Gary A.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 41 KB

english, 2010

49

Do hERG Enhancers and Blockers Compete?

Liu, Xiaoqin, Limberis, James T., Su, Zhi, Houseman, Kathryn A., Diaz, Gilbert J., Gintant, Gary A., Cox, Bryan F., Martin, Ruth L.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 43 KB

english, 2009

50

Optimization of a Cav1.2 Cell Line for Use on QPatch and PatchXpress

Martin, Ruth L., Limberis, James T., Liu, Xiaoqin, Houseman, Kathryn, Su, Zhi, Niforatos, Wende, Cox, Bryan F., Gintant, Gary A.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 65 KB

english, 2010